Dr. Frank L. Douglas Complete Bibliography

Ph.D. Thesis: Photoelectric Effects of ChlorophyllA Aggregates in Suspension, 1973

Douglas, F.L. and Albrecht, A.C.: Photoelectric Response from ChlorophyllA Microcrystals in Suspension. Chem. Phys. Letters, V14:150154, 1972

Tang, C.W.; Douglas, F.L., and Albrecht, A.C.: Photoconductivity of ChlorophyllA Films in Contact with a NonPolar Solution. J. Phys. Chem., V79(25):27232728, 1975

Douglas, F.L.: Delayed Tack Adhesives and Application to Thermography. Report No. 22488 (Xerox Sensitive). Xerox Corporation, 1973

Krishan, I. (Chairman); Douglas, F.L. (Ex officio member) et al.: The 1980 Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. Arch. Intern. Med., 140(10):12801285, 1980

Douglas, F.L. (ed.), Report on Economic Aspects of High Blood Pressure in Black Communities. Sponsored by the Advisory Committee National High Blood Pressure Education Program, NHLBI, NIH

Douglas, F.L.; Palkovits, M.; and Brownstein, M.J.: Regional Distribution of Substance Plike Immunoreactivity in the Lower Brainstem of the Rat. Brain Res., 245:376378, 1982

Douglas, F.L.; Palkovits, M.: Distribution and Quantitative Measurements of Somatostatinlike Immunoreactivity in Lower Brainstem of the Rat. Brain Res., 242:369373, 1982

Keiser, H.R.; Averbuch, S.D.; Goldstein, O.S.; Wade, J.L., Douglas, F.L.: Treatment of Malignant Pheochromocytoma with Combination Chemotherapy. Hypertension (U.S.), 7:118124, 1985

McCoy, C.E.; Douglas, F.L., and Goldberg, L.I.: Selective Antagonism of the Hypotensive Effects of Dopamine Agonists in Spontaneously Hypertensive rats. Hypertension, 8:298302, 1986

Cohen, R.M.; Herold, K.C.; Levy, J.; Douglas, F.L., and Polonsky, K.S.: Variable Deterioration in Cortical Function During InsulinInduced Hypoglycemia. Diabetes, (34):677685, 1985.

Goldberg, L.I.; Douglas, F.L.: Dopamine and Hypertension: An Expanding Avenue of Research. Drug Therapy. V15(1):8793, 1985

Sands, M.; Douglas, F.L.; Green, J.; Banner, A., and Leff, A.R.: Homeostatic Regulation of Bronchomotor Tone During Methacholine Challenge in Normal and Asthmatic Humans. Clinical Research, V33:581, 1985. 77th Annual Meeting American Society for Clinical Investigation, Washington, D.C. May 36, 1985

Rajfer, S.I.; Rossen, J.D.; Douglas, F.L.; Goldberg, L.I.; Karrison, I.: Effects of LongTerm Therapy with Oral Ibopamine on Resting Hemodynamics and Exercise Capacity in Patients with Heart Failure: Relationship to the Generation of NMethyldopamine and to Plasma Norepinephrine Levels. Circulation (U.S.), V73(4):740748, 1986

Weiss, G.; Traina, V.M.; Douglas, F.L.: Review of Hemodynamic and Toxicological Properties of Magnesium Aspartate Hydrochloride. New Cardiovascular Drugs, (Ed. A. Scriabine), 1986, pp. 243257

Douglas, P.L., et al, Augmentation of Renal Blood Flow and Sodium Excretion in Hypertensive Patients During Blood Pressure Reduction by Intravenous Administration of the Dopamine, Agonist, Fenoldopam. Circulation, 76(6):13121318, December, 1987

Gilden, J.; Douglas, F.L.; Robertson, Gary L.: Hormonal Changes Due to HypovolemicInduced Orthostatic Hypotension in Healthy Volunteers. University of Chicago. Clinical Research Vol. 32 (4) 1984. 42nd Annual Meeting of American Federation for Clinical Research, October 31November 2, 1984

Douglas, F.L.; Rajfer, S.; Rossen, J.; Nemanich, J.; Davis, F.; Osinski, J.: Sustained Hemodynamic Improvement During LongTerm Therapy with Levodopa in Heart Failure: Role of Plasma Catecholamines, 1987, Journal of the American College of Cardiology Vol. 10 (6) 1987 p. 12861293

Gilden, J.L.; Kumar, Y.; Shamsabad, F.; Singh, S.P.; Douglas, F.L.; Ellyin, F.: Hormonal Changes in Diabetic Patients with Orthostatic Hypotension. Presented at the 43rd Annual National Meeting of The American Federation For Clinical Research Washington, D.C. May 25, 1986. Clinical Research Vol. 34 (2) 1986 p. 545

Murphy, M.B.; McCoy, C.E.; Weber, R.R.; Frederickson, E.D.; Douglas, F.L.; Goldberg, L.L.: Augmentation of Renal Blood Flow and Sodium Excretion in Hypertensive Patients During Blood Pressure Reduction by Intravenous Administration of the Dopamine1 Agonist Fenoldopam. Circulation Vol. 76 (6) 1987 p. 13121318

Alijani, M.R.; Lim, K.; Douglas, F.; Turk, J.; Helfrich, G.B.; Taher, S.A.; Foegh, M.L.: Differential Effect of CGS 13080, A Thromboxane Synthase Inhibitor, in Suppressing Serum ITXB2 and Urine ITXB2 in Kidney Transplant Patients. Transplant Proceedings, 1988. Vol 20 (1 Suppl. 1) p. 424427

Mustafa, S.J.; Brown G.L.; Kotake, A.N.; Douglas, F.L., and Sabouni., N.H.: Effects of CGS 15943A on the Relaxations Produced by Adenosine Analogs in Human Blood Vessels. FASEB J3 (4) 1989 A1047. European J. of Pharm., 187 p. 525530, 1990

Weir, M.R.; Klassen, D.K.; Hoover, N.; Douglas, F.L.: Preliminary Observations of the Acute Effects of Selective Serum Thromboxane Inhibition and Angiotensin Converting Enzyme Inhibition on Blood Pressure and Renal Hemodynamics in Hypertensive Humans. Journal of Clinical Pharmacology, 1989; 29:11081116

Smeesters, C.; Chaland, P.; Giroux, L.; Moutquin, J.M.; Etienne, P.; Douglas, F.L.; Corman, J.; StLouis, G., and Daloze, P.: Prevention of Acute Cyclosporine A Nephrotoxicity by a Thromboxane Synthetase Inhibitor. Transplantation Proceedings; Vol XX (3), Suppl 3 (April),: 658664, 1988

Fedorak, R.N.; Kotake, A.; Douglas, F.L., and Chang, E.B.: Inhibition of CholeraToxin-Simulated Intestinal Secretion by CGS 9343B in Rats: A Specific Calmodulin Inhibitor Journal of Pediatric Gastroenterology and Nutrition 8: 252258, 1989

Rakhit, A.; Kuwahara, S.K.; Jones, D.R.; Soliman, V.F.; Kotake, A.N.; Ogelsby, T.D.; Wasley, J.W.; Tripp, S.L.; Douglas, F.L.: Pharmacokinetic Screening of oNaphthoquinone 5-­Lipoxygenase Inhibitors. Pharmaceutical Research, Vol. 7, No. 10, 1990

Kuwahara, S.K.; Brubaker, W.; Williams, E.; Tripp, S.L.; Douglas, F.L.; Kotake, A.N.: Determination of CGS 8515 in Plasma by High Performance Liquid Chromatography Using Reductive Electrochemical Detection. JChromatogr 1990 Dec. 14, Vol: 534, p. 2606

Coram, W.M.; Foster, C.E.; Senft, C.J.; Douglas, F.L.; Weiss, G.B.: Magnesium Aspartate HC1 and Magnesium Chloride Hexahydrate Oros: Comparative Absorption of Magnesium in Dogs. Drug Dev. Research 21 (4) P. 291300 (1990)

Coram, W.M.; Kapeghian, J.D.; Plocinski, A.F.; Toledo, L.M.; Douglas, F.L.; Weiss, G.B.: Effects of Potassium or Potassium/Magnesium Supplementation on Potassium Cont. of Body Tissues and Fluids in FurosemideTreated Rats on MagDef or MagSuf. Diet. Life Sciences Vol. 46 (1) 1990 p. 1927

Zemel, M.B.; Green, J.; Zemel, P.C.; Douglas, F.L.; Geiser, R.; Sowers, J.R.: Effects of Magnesium Supplementation on Erythrocyte Cation Transport in Diuretic Treated Hypertensives. Nutrition Research, Vol. 9, 12851292, 1989

Cardin, J.P.; Ross, M.G.; Ervin, M.G.; Schaffer, A.V.; Douglas, F.L.: Fetal and Maternal Responses to Intravenous Infusion of a Thromboxane Synthetase Inhibitor. Am. J Obstet Gynecol., 1990, Vol. 163 No. 4, Part 1, p. 13451349

Vokes, E.E.; Mick, R.; Vogelzang, N.J.; Geiser, R.; Douglas, F.L.: A Randomized Study Comparing Intermittent to Continuous Administration of Magnesium Aspartate Hydrochloride in CisplatinInduced Hypomagnesaemia. BJC, Vol. 62 p. 10151017, 1990

Fomsgaard J.; Kim, Y.; Burke, T.; Viswanathan, T.; Schaffer, A.V.; Peppard, J.; Douglas, F.L.; Danchak, M.; Myers, A.: Effects of Thromboxane Synthetase Inhibitor and Glucocorticoid on Anaphylactoid Responses to Protamine iIn Dogs. Anesth. Analg. 74 (1) 1992 p.3843

Tang, J.P.; Rakhit, A.; Douglas, F.L.; Melethil, S.: Effect of Chronic Hypertension on the BloodBrain Barrier Permeability of Libenzapril. Pharm. Res. 1992 Feb, Vol. 9 (2), p. 23643

Muehlbauer, B.; Schwenk, M.; Coram, W.M.; Antonin, K.H.; Etienne, P.; Bieck, P.R.; Douglas, F.L.: MagnesiumLAspartateHC1 and Magnesium Oxide: Multiple Dose Study on Tolerability, Pharmacodynamics & Bioavailability In Health, Volunteers. Eur. J. Clin. Pharmacol. 40 (4). 1991. p. 437438

Martin, L.L.; Schaffer, A.V.; Piraino, A.; Linberg, L.; Singh, K.; Rakhit, A.; Douglas, F.L.: Pharmacokinetics of CGS 12970 and Inhibition of Thromboxane Synthesis Following Its Oral Administration in Health, Adults. ClinPharmacolTher 1991 Apr, Vol. 49 (4), p. 44341

Paul, P.K.; O’Byrne, E.; Blancuzzi, V.; Wilson, D.; Gunson, D.; Douglas, F.L.; Wang, J.Z.; Mezrich, R.S.: Magnetic Resonance Imaging Reflects Cartilage Proteoclycan Degradation in the Rabbit Knee. Skeletal Radiol.1991, Vol. 20 (1), p. 316

O’Byrne, E.; Paul, P.K.; Blancuzzi, V.; Wilson, D.; Gunson, D.; Wang, J.Z.; Mezrich, R.S.; Douglas, F.L.: Magnetic Resonance Imaging of the Rabbit Knee: Detection of Cartilage Proteoclycan Degradation. AgentsActions 1991 Sept, Vol. 34 (12), p. 2146

Singh, K.; Wong, A.; Tripp, S.; Dunton, A.; Douglas, F.L.; Rakhit, A.: Prediction of In Vivo Hepatic Extraction Ratio in the Rat from In Vitro Metabolism by Hepatocytes. Drug Metabolism and Disposition 1991 SeptOct, Vol. 19 (5), p. 9906

Zemel, P.C.; Zemel, M.B.; Urberg, M.; Douglas, F.L.; Geiser, R.; Sowers, J.R.: Effects of Oral Magnesium Supplementation on Blood Pressure and Cellular Cation Metabolism in Patients with Essential Hypertension. American Journal Clinical Nutrition Vol. 51 (4) 1990 p. 665669

Douglas, F.: Dilemmas in Clinical Research. Scrip Magazine, June 1993

Paul, P.K.; Jasani, M.K.; Sebok, D.; Rakhit, A.; Dunton, A.W.; Douglas, F.L.: Variation in MR Signal Intensity across Normal Human Knee Cartilage. JMRI, Volume 3, Number 4 p. 569574, 1993

Dunton, A.W.; Erion, M.; Robertson, P.; Brubaker, W.E. Jr.; Williams, E.D.; Thomas, J.L.; Singh, K.; Tripp, S.L.; Douglas, F. L.: Potentiation of Nucleoside Analogue Pharmacokinetics by Purine Nucleoside Phosphorylase (PNP) Inhibitors. (Weekly Research Report). AIDS Weekly, Oct 8, 1991, p. 21 (1)

Makujina, S.R.; Sabouni, M.H.; Bhatia, S.; Douglas, F.L.; Mustafa, S.J.: Vasodilatory Effects of Adenosine A2 Receptor Agonists CGS 21680 and CGS 22492 in Human Vasculature. Eur. J. Pharmacol. 1992 Oct 20, Vol. 221 (23), p. 2437

Rajfer, S.I.; Rossen, J.D.; Nemanich, J.W.; Douglas, F.L.; Davis, F.; Osinski, J.: Sustained Hemodynamic Improvement during Long-Term Therapy with Levodopa in Heart Failure: Role of Plasma Catecholamines. J. Am. Coll. Cardiol. 1987 Dec, Vol. 10 (6), p. 128693

Tang, J.P.; Xuz, Q.; Douglas, F.L.; Rakhit, A., Melethil, S.: Increased BloodBrain Barrier Permeability of Amino Acids in Chronic Hypertension. Life Sci. 1993, Vol. 53 (25), p. PL41720

Douglas, F.L. MacKenzie, M. and Tollman, P.A.: How to spend a Billion Dollars: Two basic R&D archtypes. IN VIVO July 1998

Naraynan, V.K.; Douglas, F.L.; Guernsey, B; Charnes, John: How top management steers Fast Cycle Teams to Success. Strategy & Leadership Vol 30, (3) 2002

Douglas, F.L.: A Platform for Innovation. Reflections 2004, Vol 5 (6), p. 1-8

Naraynan, V.K., Douglas F.L. et al. Virtual Communities as an Organizational Mechnanism for Embedding Knowledge Management In Drug Development: The Case of Chemical Biology Platform. Journal of business Chemistry, 2004, 1, pp 37-46.

Naraynan, V.K., Kemmerer, B. Douglas, F.L. Guernsey, B.: The Social Construction of Organizational

Capabilities in Bala Chakravarthy et al. (Ed.) Strategy Process, Blackwell

Trusheim, M. R., Berndt E. R., Douglas, F. L., Stratified Medicine: strategic and economic implications of combining Drugs and clinical biomarkers. Nature Reviews Drug Discovery, 2007, Vol 6,  pp287-293.

Douglas, F.L. Litan, R., Fighting the War on Cancer. The Scientist Magazine, October, 2008

Orloff, J., Douglas, F., Levinson, S., et al. The Future of Drug Development:  Advancing Clinical Trial Design.  Nature Reviews Drug Discovery 8, 949-957. Dec 2009.

Nwaka S, Ramirez B, Brun R, Maes L, Douglas F, Ridley R., Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Negl Trop Dis. 2009 Aug 25;3(8):e440.

Douglas, F.L., Naraynan, V.K., The Case for Entrepreneurship in R&D in large Pharmaceutical

companies.  Nature Reviews Drug Discovery, 2010, Vol 9, pp683-689.

Lessl M.,  Douglas FL.; From Technology Transfers to Now-How Interchange.  Wissenschaftsmanagement.2, March/April, 2011

Duncan D.E., with Douglas, F. L., Molnar L.K. and Spielberg S.P.:  The Personalized Health Project, Identifying the Gaps Between Discovery and Application in the Life Sciences, and Proposed Solutions; January 2011, Ewing Marion Kauffman Foundation.

Douglas, F.L. et al:  Value-driven Engineering for US Global Competitiveness, June 2011.

Wei HJ, Wu AT, Hsu CH, Lin YP, Cheng WF, Su CH, Chiu WT, Whang-Peng J, Douglas FL, Deng WP.: The development of a novel cancer immunotherapeutic platform using tumor-targeting mesenchymal stem cells and a protein vaccine.  Mol Ther. 2011 Dec;19(12):2249-57. doi: 10.1038/mt.2011.152. Epub 2011 Jul 26.

Douglas, FL. Innovation and value-driven engineering.  Nat Rev Drug Discov. 2012 May;11(5):335.

Dr. Frank L. Douglas Abstracts 

McCoy, C.E.; Douglas, F.L., and Goldberg, L.I.: The Effects of Dopamine Agonists and Antagonists in the Spontaneously Hypertensive Rat. Clinical Research, V32:335, 1984

Sands, M.; Douglas, F.L.; Gilden, J.; Robertson, G.; Green, J.; Banner, A., and Leff, A.: Sympathetic Response during MethacholineInduced Bronchoconstriction and Orthostatic Hyportension. Clinical Research, V32:247. 1984

Rajfer, S.; Rossen, J.; Douglas, F.L.; Chosporis, N., and Goldberg, L.I.: Sustained Beneficial HemodynamicResponses to LongTerm Treatment with Oral Levodopa in Heart Failure. Clinical Research, V32:545, 1984

Sands, M.; Douglas, F.L.; Green, J.; Banner, A.; Leff, A.R.; Robertson, G.L.: Homeostasis Regulation of Bronchomotor Tone by Sympathetic Activation during Bronchoconstriction in Normal and Asthmatic Humans. American Review of Respiratory Disease, V132:993-­998, 1985

McCoy, C.E.; Frederickson, E.D.; Murphy, M.B.; Kotake, A.N.; Douglas, F.L., and Goldberg, L.I.: Effects of Dopamine (DA1) Receptor Agonist Administration in Hypertensive Patients. Hypertension, V7:848, No. 50, 1985. 39th Annual Fall Conference and Scientific Sessions on the Council for High Blood Pressure Research, Cleveland, Ohio, September 1821, 1985

McCoy, C.E.; Frederickson, E.D.; Douglas, F.L.; Murphy, M.B., and Goldberg, L.I.: Intravenous Administration of the Dopamine (DA) Receptor Agonist, Fenoldopam, in Hypertensive Patients. Journal of Hypertension, V3:548, 1985

Rossen, J.D.; Douglas, F.L.; Goldberg, L.I. and Rajfer, S.: Decline in Plasma Norepinephrine and Improved Exercise Capacity during LongTerm Oral Ibopamine Therapy in Heart Failure. Clinical Research, V33:597, 1985. 98th Annual Meeting of Association of American Physicians,  Washington, D.C.   May 36, 1985. Clin. Res. 33 (2 Part 1) 1985, 597A

Gilden, J.L.; Douglas, F.L.; Robertson, G.L.; Bausch, D.G.: Hormonal Changes Due to HypovolemicInduced Orthostatis Hypotension in HealthyVolunteers. Clinical Research, V32:730, 1984

Averbuch, S.D.; Keiser, H.R.; Wade, J.L.; Goldstein, D.S.; Douglas, F.L.: Treatment of Malignant Pheochromocytoma with Combination Chemotherapy. Clinical Research, V32:698, 1984

Keiser, H.R.; Averbuch, S.D.; Wade, J.L.; Goldstein, D.S.; Douglas, F.L.: Chemotherapy of Malignant Pheochromocytoma In Man. 38th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, Cleveland, Ohio, October 1012, 1984. Hypertension Vol. 6 (5) 1984 p. 782

McCoy, C.E.; Frederickson, E.D.; Douglas, F.L.; Murphy, M.B.; Goldberg, L.I.: Intravenous Administration of the Dopamine Receptor Agonist Fenoldopam in Hypertensive Patients. 77th Annual Meeting of the American Society for Clinical Investigation,  Washington, D.C.,   May 36, 1985. Clinical Research Vol. 33 (2 Part 1) 1985

Gilden, J.L.; Kumar, Y.; Shamsabad, F.; Singh, S.P.; Douglas, F.L.; Ellyin, F.: Hormonal Changes in Diabetic Patients with Orthostatic Hypotension. Presented at FortyThird Annual National Meeting of the American Federation for Clinical Research, Washington D.C., May 2-­5, 1986. Clin. Res. 34 (2). 1986. 545A

Coram, W.M.; Conder, M.L.; Arthur, A.T., and Douglas, F.L.: Effects of CGS 10078B on Catecholamine Content of Brain, Heart, Uterus and Plasma in Conscious Rats.  Presented, ASPET, 1986

Lass, N.A.; Murphy, M.B.; Kotake, A.; Schoeller, D.; Baker, A., and Douglas, F.L.: Evaluation of Liver Function Tests in Detecting DrugInduced Hepatotoxicity in Man. X International Congress of Pharmacology, Sydney, Australia

Chang, E.B.; Fedordak, R.N.; Kotake, A.; Douglas, F.L.: Inhibition of Cholera Toxin-­Stimulated Intestinal Secretion By CGS 93438 in Rats: A Potent and Specific Inhibitor of Calmodulin. Journal of Pediatric Gastroenterology. 88th Annual Meeting American Gastroenterological Assn. and Digestive Disease Week, Chicago, IL, May 915, 1987. Gastroenterology 92 (5 Part 2). 1987, p.l341

Balk, R.A.; Harshbarger, R.; Szidon, J.P.: Bone, R.C.; Douglas, F.L.: CGS 13080 Improves the Hemodynamic and Oxygenation Derangements of Canine Edotoxin Shock. 1987 ATS Annual Meeting

Cardosco, S.; Burghen, G.; Sibai, B.; Barelski, P.; Shafi, I.; Arafat, S.; Perry, E.; Ray, J.; Douglas, F.: Vasomotor Function Tests in the Assessment of Human Health and Disease. Presented at the Spring FASEB Meeting 1987.  Federation Proceedings: Vol. 476 (3) 1987 p. 421

Rakhit, A.; Kuwahara, S.; Soliman, V.; Kotake, A.; Douglas, F.: Unusual Pharmacokinetics of a Novel Inverse Benzodiazepine Agonist, CGS 8216 in Dog. Presented at the ASPET meeting in Honolulu, Hawaii, August, 1987

Sandmann, B.J.; Strickland, W.; Douglas, F.; Kotake, A.; Nagy, I.: Formulation of an Intravenous Solution for a Water Insoluble Drug. JUC Pharmaceutical Science: Vol. 76 (11) 1987 S295. Joint Japan USA Congress of Pharmaceutical Sciences, Honolulu, Hawaii, December 27, 1987

Vermeulen, J.D.; Kuwahara, S.K.; Thompson, T.A.; Kotake, A.N.; Tripp, S.L.; Douglas, F.: HPLC Gradient Separation of Eight Urinary Metabolites of CGS 8216. Presented at the September, 1987, American Association of Pharmaceutical Sciences Eastern Regional Meeting

Weir, M.R.; Klassen, D.; Hoover, N.; Douglas, F.: Effects of a Thromboxane Synthetase-­Inhibitor (CGS 13080) on Blood Pressure, Renal Hemodynamics and Prostaglandin (PG) Production in Hypertensive Humans. Presented at the American Society of Hypertension Annual Meeting in June, 1988

Gilden, J.L.; Singh, S.P.; Vega, D.; Fulambarker, A.; Douglas, F.L.: Role of Endogenous Opioids on Glucose Homeostasis during Exercise in Normals and Patients with Insulin-­Dependent Diabetes Mellitus. Presented at the XIIIth Congress of the International Diabetes Federation, Sydney, Australia, November 2025, 1988. Diabetes Research & Clinical Practice Vol. 5, (Suppl. 1) 1988 S534

Gilden, J.L.; Singh, S.P.; Douglas, F.L.: Ethanol Intake and Autonomic Function in Diabetic Patients with Orthostatic Hypotension. Presented at the 45th Annual National Meeting of the American Federation for Clinical Research, Washington, D.C., April 29May 2, 1988. Clinical Research Vol. 36 (3) 1988 482A

Pamnani, M.B.; Rinaudo, M.S.; Mueller, G.P.; Link, W.T.; Douglas, F.L.; Ghia, R.G.; Haddy, F.J.: Measurement of Atrial Tissue Natriuretic Factor ANF Levels in Two Models of Hypertension. Presented at the 72nd Annual Meeting of the Federation of American Societies for Experimental Biology, Las Vegas, Nevada,  May 15, 1988. FASEB J 2 (5) 1988

Paul, P.; Mezrich, R.; Douglas, F.: Inflammatory Joint Disease Study by MRI. Submitted to the 74th Scientific Assembly of The Radiological Society of North America, November 27­-December 2, 1988 Meeting

Murphy, M.B.; Zebrauskas, D.; Schutte, S.; Wood, R.; Geiser, R.; Douglas, F. L.; Elliott, W.J.: Oral Magnesium Supplementation in Diuretic Treated Patients.   Presented at American Society of Hypertension, New York, New York, May 1012, 1989

Rahkit, A.; Robertson, P.; Thompson, T.N.; Turk, J.; Kotake, A.N.; Foegh, M.L.; Douglas, F.L.: Pharmacokinetics of CGS 13080, A Thromboxane Synthase Inhibitor in Kidney Transplant Patients.  Presented at IV World Conf. on Clinical Pharmacology & The Rapeutics, Heidelberg, July 2328, 1989

Paul, P.K.; Mezrich, R.; Wang, J.Z.; Goldberg, R.L.; Rubin, A.S.; Douglas, F.L.: Soft Tissue Quantification by MRI to Study the Progress of Joint Inflammation. Presented at SMRM Eighth Annual Meeting, Amsterdam, Holland, August 22, 1989

Piraino, A.J.; Saris, S.D.; Douglas, F.L.; Schaffer, V.: CGS 12970 Protocol 01. Presented at American College of Clinical Pharmacology Meetings, Baltimore, MD, October 1113, 1989

Paul, P.K.; Rubin, A.S.; Wang, J.; Mezrich, R.S.; Douglas, F.L.: MRI T2 Relaxation Time Reflects the Inflammatory Changes in an Arthritis Rat Model at Multiple Time Points. Presented at IEEE/Engineering in Medicine & Biology Society, Seattle, WA, November 9, 1989

Sabouni, M.H.; Brown, G.L.; Kotake, A.N.; Douglas, F.L.; Mustafa, S.J.: Effects of CGS 15943A on the Relaxations Produced by Adenosine Analogs in Human Blood Vessels. Eur. J. Pharmacol. 1990, Oct. 23, Vol. 187 (3), p. 52530

Coffman, T.M.; Smith, S.R.; Creech, E.A.; Schaffer, A.V.; Martin, L.L.; Rakhit, A.; Douglas, F.L.; Notman, P.E.: the Thromboxane (TX) Synthetase Inhibitor CGS 13080 Improves Renal Allograft Function in Patients Taking Cyclosporine (CYA). Kidney Int’l: Vol. 37 (1) 1990, p. 604. Presented at the American Society of Nephrology 22nd Annual Meeting, Washington, D.C.,  ecember 36, 1989

Chovan, J.; Zane, P.A.; Tripp, S.L., Douglas, F.L.; Robertson, P.: The Pharmacokinetics of CGS 21680, a Novel Antihypertensive Agent, in SpragueDawley (SD) and Spontaneously Hypertensive Rats (SHR). Presented at FASEB Annual Meeting, Washington, D.C.,  pril 15, 1990. FASEB J4 (3). 1990. A462

Martin L.L.; Abbott, V.; Hamilton, B.; Linberg, L.; Kotake, A.; Rakhit, A.; Douglas, F.L.: Determination of CGS 12970 in Plasma by GC/MS. Presented at American Society For Mass Spectrometry, Tucson, AZ, June 38. 1990

Linberg, L.F.; Martin, L.L.; Rakhit, A.; Douglas, F.L.: A Simple Method for Gas ChromatographicMass Spectrometric Determination of Thromboxanes and Prostaglandins in Urine. Presented at American Society for Mass Spectrometry, Tucson, AZ, June 38, 1990

Wang, J.Z.; Mezrich, R.S.; Als, A.V.; Paul, P.K.; Dunton, A.W.; Douglas, F.L.: Automated Segmentation of MR Images for 3D Solid Rendering. Presented at Society of Magnetic Resonance in Medicine, New York,  ugust 1824, 1990

Wang, J.Z.; Mezrich, R.S.; Paul, P.K.; Rakhit, A.; Dunton, A.W.; Douglas, F.L.: An Algorithm for Accurate Cartilage Thickness Quantification from MR Images. Presented at Society of Magnetic Resonance in Medicine, New York,  ugust 1824, 1990

Schaffer, A.V.; Rakhit, A.; Martin, L.; Hanie, L.; Sibai, B.; Ross, M.G.; Dunton, A.W.; Douglas, F.L.: The Thromboxane/Prostacyclin Ration in Preeclampsia: A Potential Biochemical Market. Presented at VII Congr. of Intern. Society for Study of Hypertension in Pregnancy, Pergugia, Italy, October, 1990

Paul, P.K.; Wang, J.Z.; Mezrich, R.S.; Rakhit, A.; Dunton, A.W.; Furst, D.; Douglas, F.L.: 3DMRI: A Novel Approach to Quantitation of Articular Cartilage. 54th Annual Meeting of the American College of Rheumatology, Seattle, Washington, October 27November 1, 1990. Arthritis. Rheum. 33 (9 Suppl.). 1990. S91

Paul, P.K.; Stevens, R.M.; Mezrich, R.S.; Goldberg, R.L.; Doughty, J.R.; Dunton, A.W.; Douglas, F.L.; Rakhit. A.: Magnetic Resonance Imaging Evaluation of Therapy in Rheumatoid Arthritis. NinetyThird Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, Orlando, Florida, March 1820, 1992. Clin. Pharmacol. Ther. 51 (2). 1992. 193

Sabouni, M.H.; Bhatia. S.; Douglas, F.L.; Mustafa, S.J.: Different Relaxation Characteristics of the Adenosine Analogs in Human Blood Vessels. 75th Annual Meeting of the Federation of American Societies for Experimental Biology, Atlanta, Georgia, April 2125, 1991. FASEB Fed. Am. Soc. Exp. Biol. J 5 (6). 1991. A1573

Kim, Young D.; Foegh, Marie L.; Wallace, Robert B.; Ng, Lily; Katz, Nevin M.; Siegelman, Richard; Franco, Kenneth; Douglas, Frank; Ku, Edward; Sen, S. Ben; Ramwell, Peter; Georgetown University Hospital, Washington, D.C.: Effects of CGS 13080, A Thromboxane Inhibitor on Pulmonary Vascular Resistance in Patients after Mitral Valve Replacement Surgery.  Presented at the American Heart Association Meeting in November, 1987 in Anaheim, California. Circulation: Sept 1988 Vol. 78 (3P2) p. 144-­150

Barton, J.R.; Sibai, B.M.; Schaffer, A.V.; Rakhit, A.; Martin, L.L.; Hanie, L.K.; Dunton, A.W.; Douglas, F.L.: Urinary Excretion of Thromboxane Metabolites in Preeclampsia during Intravenous MG S04 Therapy. Presented at VII Congr. of Intern. Soc. for Study of Hyperten. in Pregnancy, Perguguia, Italy, October 7, 1990

Martin, L.L.; Schaffer, A.V.; Rakhit, A.; Dunton, A.W.; Douglas, F.L.; Coffman, T.M.: Pharmacokinetic and Biochemical Profile of CGS 13080 in Renal Allograft Recipients with Cyclosporine Nephrotoxicity. Clin. Pharmacol. Ther. 49 (2) 1991. p. 194

Wang, J.Z.; Mezrich, R.S.; Paul, P.K.; Dunton, A.W.; Douglas, F.L.: An Algorithm for Accurate Cartilage Thickness Quantification from MR Images

Ali, S.; Mustafa, S.J.; Rakhit, A.; Douglas, F.L.; Metzger, J.: Modification of AllergenInduced Airway Obstruction and Bronchial Hyperresponsiveness in Allergic Rabbits by CGS12970. 75th Annual Meeting of Federation of American Societies for Experimental Biology, Atlanta, Georgia, April 2125, 1991. FASEB Fed. Am. Soc. Exp. Biol. J5 (5991). 1991. A1243

Paul, P.; O’Byrne, E.; Blancuzzi, V.; Wilson, D.; Douglas, F.L.; Wang, J.; Mezrich, S.: Magnetic Resonance Imaging Reflects Cartilage Proteoglycan Degradation in the Rabbit Knee. Presented at RSNA 75th Annual Meeting, Chicago, Illinois, November 25-­December 1, 1989. Skeletal Radiol. 1991, Vol. 20 (1), p. 316

Ali, S.; Mustafa, S.J.; Bhatia, S.C.; Douglas, F.L.; Metzger, W.J.: Effects of CGS15943 on AdenosineInduced Bronchoconstriction in Allergic Rabbits. Presented at the Annual Meeting of the Federation of American Societies for Experimental Biology, Part I, Washington, D.C.,  April 15, 1990. FASEB J 4 (3) 1990 A613

Cardin, J.P.; Ross, M.G.; Ervin, M.G.; Schaffer, V.; Douglas, F.L.: Starvation Induced Ovine Toxemia A. Reevaluation. Presented at the Annual Meeting of the Western Society for Pediatric Research, Carmel, California,  February 69, 1990. Clinical Research Vol. 38 (1) 1990

Weiss, G.; Zimmerman, M.B.; Coram, W.M., and Douglas, F.L.: Effects of Ascending Doses of OrallyAdministered Magnesium Aspartate Hydrochloride in Conscious Normotensive Dogs. Journal of the American College of Nutrition, V4:377, 1985. Symposium on Nutrition in Cardiovascular Disease and Diabetes Mellitus and Other Advances in Clinical Nutrition 26th Annual Meeting American College of Nutrition and 4th Int’1 Symposium on Magnesium, Blacksburg, VA,  July 2128, 1985

Dunton, A.W.; Erion, M.; Robertson, P.; Brubaker, W.F., Jr.; Williams, E.D.; Thomas, J.L.; Singh, K.; Tripp, S.L.; Douglas, F.L.: Potentiation of Nucleoside Analogue Pharmacokinetics by Purine Nucleoside Phosphorylase PNP Inhibitors. Thirtyfirst Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Illinois, September 29October 2, 1991. Program Abstr 31 (0). 1991. 216

Pamnani, M.B.; Bryant, H.J.; Chen, S.; Douglas, F.L.; Haddy, F.J.; Yuan, C.M.; Schooley, J.F.; Ghai, R.D.: Effect of Two Angiotensin Converting Enzyme ACE Inhibitors in Rats with Renin Dependent Hypertension HT. Meeting of the Federation of American Societies for Experimental Biology on Experimental Biology ’93, New Orleans, Louisiana, March 28April 1, 1993. FASEB. Fed. Am. Soc. Exp. Biol. J 7 (34). 1993. A546

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